Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle
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چکیده
منابع مشابه
New developments in nondepolarizing muscle relaxants.
Anesthesiologists perceive that the ideal muscle relaxant is not yet available, particularly the nondepolarizing one with a rapid onset and a short duration of action. There is also a need for relaxants with different durations of action but which would be free from side effects. During the process of this development several new compounds have been tested and four have reached an advanced stat...
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We report the lateral mobility of extrajunctional acetylcholine receptors (AChR), marked with fluorescently labeled alpha-bungarotoxin, on rat flexor digitorum brevis single muscle fibers maintained in cell culture. Mobility is measured by a modification of the fluorescence photobleaching recovery technique. The denervated rat flexor digitorum brevis muscle fibers exhibit a nonuniform distribut...
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STUDY OBJECTIVE To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidity using a well-established, previously described clinical protocol. DESIGN Prospective, controlled, single-blind, partially randomized study. SETTING Large medical center. PATIENTS ASA physical status I-III patients undergoing elective surgical procedure...
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Muscular dystrophy in the mouse, as in man, is considered to be a genetically determined primary myopathy in which abnormalities of motor innervation are secondary to degeneration of muscle fibres (cf. Harman, Tassoni, Curtis, and Hollinshead, 1963). In the mouse, however, there is now evidence to indicate that the motor nerve supply to a fibre may be affected at a stage in the disease when the...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2010
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2010.163